Generally, the refraction index of the lens in your glasses will be that of normal glass (can't think what this is off the top of my head, but there's a handy table in the back of Dan Ablans Simply Lightwave Books). The refraction index should be constant. The prescription value is a measure of the strength of the lens. This link should tell you all you need to know:
http://www.hon.ch/Library/Theme/Visi...tion2.html#2.1