Pretty much nothing apart from that a game model is one that has either been extracted from, or prepared for a specific game engine.
Most game engines have specific requirements for their models such as all polygons must be triangles, UV maps must be continuous, no application specific surfaces can be applied (ie no shaders), lightmaps may also need to be baked into the textures too.
Whereas a low poly model is simply a normal Lightwave (or 3DS, or Maya, etc) model with all normal surfacing attributes, shaders, etc native to that application that has a low number of polygons.
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